Why an implant rejected by the body?

Conclusion: A thorough understanding of the biological reactions to implanted materials is necessary for the development of novel biomaterials, biomedical devices, or tissue-engineered constructions. The creation of foreign body giant cells at the tissue/material interface is the final result of a series of events that start in the surrounding tissue as soon as a biomaterial enters the body. Reactions on a material's surface can have catastrophic results. Acute and chronic implant rejection reactions can impact a variety of organs and tissues and lead to major problems in clinical practice during transplantation as well as the introduction of biocompatible materials.As shown in this study, there are three aspects of cellular and humoral immunity and allergic reactions of the body to implant, that lead to implant rejection. 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